The Rossman Fold
[aka NAD(P)-binding fold]

A Rossman Fold generally contains the following elements:
1) a RH beta/alpha/beta motif,
2) a phosphate binding consensus sequence, GXGXXG,
3) six small hydrophobic residues,
4) a basic residue (Arg or Lys) at the beginning of the first beta strand,
5) a basic residue (Glu or Asp) at the end of the second beta strand.

NAD(P)-binding Rossmann-folds are contained in the following:

Tyrosine-dependent oxidoreductases

Short-chain dehydrogenases

Dihydropteridin reductase

UDP-galactose epimerase

Enoyl-ACP reductase

Lactate dehydrogenase

Malate dehydrogenase

Alcohol dehydrogenase

Glucose dehydrogenase

Quinone reductase

Formate dehydrogenase

Formate dehydrogenase

D-Glycerate dehydrogenase

Phosphoglycerate dehydrogenase

Glyceraldehyde-3-phosphate dehydrogenase

Glucose-6-phosphate dehydrogenase

Dihydrodipicolinate reductase

6-Phosphogluconate dehydrogenase

Acyl-CoA dehydrogenase

Except for ADP-ribosylation toxins, which utilize NAD as substrate, all these enzymes are oxidoreductases, which use NAD or NADP as cofactor.